SelectedWorks - Ian C. Schneider

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Selected Works of Ian C. Schneider

Associate Professor of Chemical and Biological Engineering

Research Interests
	 Cell and Biomolecular Engineering
	 Quantitative Light Microscopy
	 Biosensors
	 Cell Adhesion, Migration and Communication
	 Mechanical and Biophysical Aspects of Cell Biology

Works
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About Ian C. Schneider

Research Interests
	 Cell and Biomolecular Engineering
	 Quantitative Light Microscopy
	 Biosensors
	 Cell Adhesion, Migration and Communication
	 Mechanical and Biophysical Aspects of Cell Biology

Present	Associate Professor, Iowa State University ‐ Department of Chemical and Biological Engineering
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Biological Engineering and Chemical Engineering

Cell and Biomolecular Engineering, Quantitative Light Microscopy, Biosensors, Cell Adhesion, Migration and Communication, and Mechanical and Biophysical Aspects of Cell Biology

Damon Runyon-Rachleff Innovation Award Semi-Finalist (2010)
Sigma Xi National Research Honor Society member (2011-present)
Damon Runyon Cancer Research Foundation Postdoctoral Research Fellow (2006-2008)

CH E 356 - Transport Phenomena I

3053 Sweeney

Ames, IA 50011-2230

Phone: 515-294-0450

Email:

Peer-Reviewed Articles (28)

Cancer cell migration in collagen-hyaluronan composite extracellular matrices

Acta Biomaterialia (2021)

Shalini R. Unnikandam Veettil, Dohgyu Hwang, Jacinta Correia, Michael D. Bartlett, et al.

Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness. While the ...

Tuning Surface Functionalization Collagen Gel Thickness to Regulate Cancer Cell ...

Colloids and Surfaces B: Biointerfaces (2019)

Shalini R. Unnikandam Veettil, Shawn M. Van Bruggen, Doh-Gyu Hwang, Michael D. Bartlett, et al.

Cancer cells have a tremendous ability to sense and respond to extracellular matrix (ECM) stiffness, modulating invasion. The magnitude of ...

Pentablock copolymer micelle nanoadjuvants enhance cytosolic delivery of antigen and ...

ACS Biomaterials Science and Engineering (2019)

Sujata Senapati, Ross J. Darling, Darren Loh, Ian C. Schneider, et al.

As the focus has shifted from traditional killed or live, attenuated vaccines towards subunit vaccines, improvements in vaccine safety have ...

Degradation and Remodeling of Epitaxially Grown Collagen Fibrils

Cellular and Molecular Bioengineering (2019)

Juan Wang, Anuraag Boddupalli, Joseph Koelbl, Dong Hyun Nam, et al.

Introduction: The extracellular matrix (ECM) in the tumor microenvironment contains high densities of collagen that are highly aligned, resulting in ...

Transfer of assembled collagen fibrils to flexible substrates for mechanically ...

Integrative Biology (2018)

Juan Wang, Joseph Koelbl, Anuraag Boddupalli, Zhiqi Yao, et al.

Contact guidance or bidirectional migration along aligned fibers modulates many physiological and pathological processes such as wound healing and cancer ...

Microtissue size and cell-cell communication modulate cell migration in arrayed ...

Biomedical Microdevices (2018)

Jacob A. M. Nuhn, Shenmin Gong, Xiangchen Che, Long Que, et al.

Cells communicate through the extracellular matrix (ECM) in many physiological and pathological processes. This is particularly important during cell migration, ...

On-Chip Studies of Magnetic Stimulation Effect on Single Neural Cell ...

ACS Applied Materials & Interfaces (2018)

Xiangchen Che, Joseph Boldrey, Xiaojing Zhong, Shalini Unnikandam-Veettil, et al.

Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique, an FDA-approved treatment method for various neurological disorders such as depressive ...

Contact guidance diversity in rotationally aligned collagen matrices

Acta Biomaterialia (2018)

Jacob A. M. Nuhn, Anai M. Perez and Ian C. Schneider

Cancer cell metastasis is responsible for approximately 90% of deaths related to cancer. The migration of cancer cells away from ...

Direct expression of active human tissue inhibitors of metalloproteinases by ...

Microbial Cell Factories (2017)

Ki Baek Lee, Dong Hyun Nam, Jacob A. M. Nuhn, Juan Wang, et al.

Background As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal ...

Myosin phosphorylation on stress fibers predicts contact guidance behavior across ...

Biomaterials (2017)

Juan Wang and Ian C. Schneider

During cancer progression the extracellular matrix is remodeled, forming aligned collagen fibers that proceed radially from the tumor, resulting in ...

High Throughput Studies of Cell Migration in 3D Microtissues Fabricated ...

Micromachines (2016)

Xiangchen Che, Jacob A. M. Nuhn, Ian C. Schneider and Long Que

Arrayed three-dimensional (3D) micro-sized tissues with encapsulated cells (microtissues) have been fabricated by a droplet microfluidic chip. The extracellular matrix ...

Epitaxially Grown Collagen Fibrils Reveal Diversity in Contact Guidance Behavior ...

Langmuir (2015)

Juan Wang, Joseph W. Petefish, Andrew C. Hillier and Ian C. Schneider

Invasion of cancer cells into the surrounding tissue is an important step during cancer progression and is driven by cell ...

Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity ...

The FASEB Journal (2014)

Amanda Haage and Ian C. Schneider

The pathogenesis of cancer is often driven by local invasion and metastasis. Recently, mechanical properties of the tumor microenvironment have ...

Matrix metalloproteinase-14 is a mechanically regulated activator of secreted MMPs ...

Biochemical and Biophysical Research Communications (2014)

Amanda Haage, Dong Hyun Nam, Xin Ge and Ian C. Schneider

Matrix metalloproteinases (MMPs) are extracellular matrix (ECM) degrading enzymes and have complex and specific regulation networks. This includes activation interactions, ...

The Number of Lines a Cell Contacts and Cell Contractility ...

Cellular and Molecular Bioengineering (2014)

Nicholas R. Romsey, Yue Hou, Laura L Rodriguez and Ian C. Schneider

Cell migration is an important biological function that impacts many physiological and pathological processes. Often migration is directed along various ...

Collagen attachment to the substrate controls cell clustering through migration

Physical Biology (2014)

Yue Hou, Laura L Rodriguez, Juan Wang and Ian C. Schneider

Cell clustering and scattering play important roles in cancer progression and tissue engineering. While the extracellular matrix (ECM) is known ...

Directed cell migration in multi-cue environments

Integrative Biology (2013)

Laura Lara Rodriguez and Ian C. Schneider

Cell migration plays a critical role in development, angiogenesis, immune response, wound healing and cancer metastasis. During these processes, cells ...

Mixed-surface, Lipid-tethered Quantum Dots for Targeting Cells and Tissues

Colloids and Surfaces B: Biointerfaces (2012)

Yanjie Zhang, Amanda Haage, Elizabeth M. Whitley, Ian C. Schneider, et al.

Quantum dots (QDs), with their variable luminescent properties, are rapidly transcending traditional labeling techniques in biological imaging and hold vast ...

Differences in adhesion and protrusion properties correlate with differences in ...

BMC Biophysics (2012)

Yue Hou, Sarah Hedberg and Ian C. Schneider

Background: Cell migration plays an essential role in many biological processes, such as cancer metastasis, wound healing and immune response. ...

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

Annual Review of Cell and Developmental Biology (2010)

Margaret L. Gardel, Ian C. Schneider, Yvonne Aratyn-Schaus and Clare M. Waterman

Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. ...

Myosin II activity regulates vinculin recruitment to focal adhesions through ...

Journal of Cell Biology (2010)

Ana M. Pasapera, Ian C. Schneider, Erin Rericha, David D. Schlaepfer, et al.

Focal adhesions (FAs) are mechanosensitive adhesion and signaling complexes that grow and change composition in response to myosin II-mediated cytoskeletal ...

EGF-induced Contraction Regulates Paxillin Phosphorylation to Temporally Separate Traction Generation ...

Molecular Biology of the Cell (2009)

Ian C. Schneider, Cristen K. Hays and Clare M. Waterman

Directed cell migration is mediated by cycles of protrusion, adhesion, traction generation on the extracellular matrix and retraction. However, how ...

Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate ...

Molecular Biology of the Cell (2009)

Ian C. Schneider, Cristen K. Hays and Clare M. Waterman

Directed cell migration is mediated by cycles of protrusion, adhesion, traction generation on the extracellular matrix and retraction. However, how ...

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts

Journal of Cell Biology (2005)

Ian C. Schneider and Jason M. Haugh

Migration of eukaryotic cells toward a chemoattractant often relies on their ability to distinguish receptor-mediated signaling at different subcellular locations, ...

Spatial analysis of 3′ phosphoinositide signaling in living fibroblasts, III ...

Biophysical Journal (2005)

Ian C. Schneider, Elizabeth M. Parrish and Jason M. Haugh

Activation of phosphoinositide (PI) 3-kinase is a required signaling pathway in fibroblast migration directed by platelet-derived growth factor. The pattern ...