Skip to main content
Article
Newly identified stress-responsive protein kinases KRS-1 and KRS-2
Proceedings of the National Academy of Sciences (1996)
  • LK Taylor
  • Hwa-Chain Robert Wang, University of Tennessee, Knoxville
  • RL Erikson
Abstract
The activation of protein kinases is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. However, when several agents result in the activation of the same enzymes, it is unclear how specific biological responses are generated. We describe here two protein kinases that are activated by a subset of stress conditions or apoptotic agents but are not activated by commonly used mitogenic stimuli. Purification and cloning demonstrate that these protein kinases are members of a subfamily of kinases related to Ste20p, a serine/threonine kinase that functions early in a pheromone responsive signal transduction cascade in yeast. The specificity of Krs-1 and Krs-2 activation and their similarity to Ste20p suggest that they may function at an early step in phosphorylation events that are specific responses to some forms of chemical stress or extreme heat shock.
Publication Date
1996
Citation Information
LK Taylor, Hwa-Chain Robert Wang and RL Erikson. "Newly identified stress-responsive protein kinases KRS-1 and KRS-2" Proceedings of the National Academy of Sciences Vol. 93 Iss. 19 (1996)
Available at: http://works.bepress.com/hwa-chain_wang/8/