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Article
Comparison of Visually Evoked Local Field Potentials in Isolated Turtle Brain: Patterned Versus Blank Stimulation
Journal of Neuroscience Methods
  • Qingfei Luo
  • Huo Lu, Philadelphia College of Osteopathic Medicine
  • Hanbing Lu
  • Yihong Yang
  • Jia-Hong Gao
Document Type
Article
Publication Date
3-15-2010
Abstract
Isolated turtle brain/eye preparation has recently been used as a bloodless animal model for detecting the magnetic resonance imaging (MRI) signal changes produced by visually evoked neuronal currents. The present work aims to determine whether checkerboard-patterned or full field flash (blank) stimulation should be used in order to achieve stronger neuronal responses in turtle brain/eye preparation. The knowledge gained in this study is essential for optimizing the visual stimulation methods in functional neuroimaging studies using turtle brain/eye preparation. In this study, visually evoked local field potentials (LFPs) were measured and compared in turtle visual cortex and optic tectum elicited by checkerboard and full field flash stimuli with three different inter-stimulus intervals (ISIs=5, 10, and 16s). It was found that the behavior of neuronal adaptation in the cortical and tectal LFP signals for checkerboard stimulation was comparable to flash stimulation. In addition, there was no significant difference in the LFP peak amplitudes (ISI=16s) between these two stimuli. These results indicate that the intensity of neuronal responses to checkerboard is comparable to flash stimulation. These two stimulation methods should be equivalent in functional neuroimaging studies using turtle brain/eye preparation.
PubMed ID
20034520
Comments

This article was published in Journal of Neuroscience Methods, Volume 187, Issue 1, March 15, 2010, Pages 26-32.

The published version is available at http://dx.doi.org/10.1016/j.jneumeth.2009.12.005

Copyright © 2010 Elsevier B.V.

Citation Information
Qingfei Luo, Huo Lu, Hanbing Lu, Yihong Yang, et al.. "Comparison of Visually Evoked Local Field Potentials in Isolated Turtle Brain: Patterned Versus Blank Stimulation" Journal of Neuroscience Methods Vol. 187 Iss. 1 (2010) p. 26 - 32
Available at: http://works.bepress.com/huo_lu/3/