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Modeling mGluR1 Mediated Synaptic Depression in Cerebellar Purkinje Cells
Research Day
  • Yizhen Su, Philadelphia College of Osteopathic Medicine
  • Huo Lu, Philadelphia College of Osteopathic Medicine
Location
Georgia Campus
Start Date
7-5-2014 1:00 PM
Description
In our previous study, we have successfully simulated mGluR1 mediated sEPSP based on experimental and is associated with parallel fiber – Purkinje cell LTD [1, 2, 3]. Recent studies have shown that the mGluR1 mediated sEPSP is generated by calcium signaling through the TRPC channel which is crucial in cerebellar LTD induction [4]. Behavior study using mutant mice that lack this type of LTD has shown no motor learning impairment [5]. We hypothesize that cerebellar TRPC mediated synaptic depression shifts the excitatory and inhibitory balance to down regulate ongoing simple-spike activity. To test our hypothesis we modified our previous model of a Purkinje cell [6, 7] to have TRPC channel current signal linked to the AMPA channel conductance through Kinetikit [8].
Citation Information
Yizhen Su and Huo Lu. "Modeling mGluR1 Mediated Synaptic Depression in Cerebellar Purkinje Cells" (2014)
Available at: http://works.bepress.com/huo_lu/1/