![](https://d3ilqtpdwi981i.cloudfront.net/d0cvjeLr16dysQt4gU6G2BqoZ_4=/425x550/smart/https://bepress-attached-resources.s3.amazonaws.com/uploads/2d/40/8d/2d408d51-6cf6-4752-b4bc-13f23a25e09e/thumbnail_31f6bd66-83d2-489f-ac6c-8c627a2020a4.jpg)
In our previous study, we have successfully simulated mGluR1 mediated sEPSP based on experimental and is associated with parallel fiber – Purkinje cell LTD [1, 2, 3]. Recent studies have shown that the mGluR1 mediated sEPSP is generated by calcium signaling through the TRPC channel which is crucial in cerebellar LTD induction [4]. Behavior study using mutant mice that lack this type of LTD has shown no motor learning impairment [5]. We hypothesize that cerebellar TRPC mediated synaptic depression shifts the excitatory and inhibitory balance to down regulate ongoing simple-spike activity. To test our hypothesis we modified our previous model of a Purkinje cell [6, 7] to have TRPC channel current signal linked to the AMPA channel conductance through Kinetikit [8].
Available at: http://works.bepress.com/huo_lu/1/