PURPOSE: Heart failure (HF) is the leading cause of hospitalizations, readmissions and hospital costs in the United States. Although a significant improvement in the management of HF has been made by multidisciplinary teams in the past years, the impact of pharmacists’ interventions has not been clearly established. The purpose of this meta-analysis was to investigate the effect of pharmacists’ interventions on readmission rate after discharge in HF patients. METHODS: A systematic search was conducted for English-language articles published from database inception to May 2014. We included randomized controlled trials that reported the pharmacists’ interventions and readmission rate within 30 days to 12 months after discharge. The numbers of patients with readmissions were analyzed using MIX 2.0 (Version 2.0.1.4. BiostatXL, 2011). RESULTS: Six studies met all criteria. Pharmacists’ interventions include but not limited to medication reconciliation, medication initiation, dose titration, and patients education. One hundred and forty one patients were readmitted during follow-up period in the pharmacists’ interventions group (n = 423), compared to one hundred and forty two patients in the usual care control group (n = 412). There was no statistically significant difference in the readmission rate between the pharmacists’ intervention group and the usual care control group (OR = 0.84, 95% CI: 0.49–1.46; p=0.54). A random effects model was used as the heterogeneity between the studies was significant (Q = 13.58, df = 5; p=0.019; I2 = 63.18%). CONCLUSION: The results of our meta-analysis indicate that pharmacists’ interventions in the treatment of HF patients have no effect on readmission rate within 30 days to 12 months after discharge. The heterogeneity could be explained by differences in sample size, interventions, and treatment duration. Our results are consistent with HOOPS study that pharmacists’ interventions do not improve clinical outcomes in HF patients.