Article
Micro-Channel Diffusion Characteristics of an Implantable Drug Delivery Device for Age-Related Macular Degeneration
Microsystem Technologies
Abstract
There is an increasing need to develop implantable drug delivery devices for effective therapeutic management of chronic ocular diseases such as age-related macular degeneration (AMD). In this work, we designed four different micro-channel configurations for an implantable device and elucidate drug diffusion characteristics using both simulation and experimental measurements. Our simulation and experimental results show that three micro-channel configurations are capable of sustaining drug release and can be incorporated into an implantable device to exert long-term drug release required for therapeutic management of AMD.
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
- Implants (surgical), Age-related macular degeneration,
- Diffusion characteristics,
- Drug diffusion,
- Drug release,
- Implantable devices,
- Implantable drug delivery,
- Ocular disease, Ophthalmology
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2015 Springer Verlag, All rights reserved.
Publication Date
9-21-2015
Publication Date
21 Sep 2015
Disciplines
Citation Information
Ramana M. Pidaparti, Jae-Hwan Lee and Hu Yang. "Micro-Channel Diffusion Characteristics of an Implantable Drug Delivery Device for Age-Related Macular Degeneration" Microsystem Technologies Vol. 21 Iss. 9 (2015) p. 1967 - 1974 ISSN: 0946-7076; 1432-1858 Available at: http://works.bepress.com/hu-yang/46/