There is an increasing need to develop implantable drug delivery devices for effective therapeutic management of chronic ocular diseases such as age-related macular degeneration (AMD). In this work, we designed four different micro-channel configurations for an implantable device and elucidate drug diffusion characteristics using both simulation and experimental measurements. Our simulation and experimental results show that three micro-channel configurations are capable of sustaining drug release and can be incorporated into an implantable device to exert long-term drug release required for therapeutic management of AMD.