Article
Electrospun Gelatin-arabinoxylan Ferulate Composite Fibers for Diabetic Chronic Wound Dressing Application
International Journal of Polymeric Materials and Polymeric Biomaterials
Abstract
Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby—Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.
Department(s)
Chemical and Biochemical Engineering
Research Center/Lab(s)
Center for Research in Energy and Environment (CREE)
Comments
This work was supported, in part, by the National Science Foundation (CAREER award CBET0954957).
Keywords and Phrases
- Arabinoxylan,
- chronic wound,
- diabetes,
- electrospinning,
- gelatin,
- nanofiber,
- wound dressing
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2019 Taylor & Francis, All rights reserved.
Publication Date
7-24-2019
Publication Date
24 Jul 2019
Disciplines
Citation Information
Donald C. Aduba, Seon-Sook An, Gretchen S. Selders, W. Andrew Yeudall, et al.. "Electrospun Gelatin-arabinoxylan Ferulate Composite Fibers for Diabetic Chronic Wound Dressing Application" International Journal of Polymeric Materials and Polymeric Biomaterials Vol. 68 Iss. 11 (2019) p. 660 - 668 ISSN: 0091-4037; 1563-535X Available at: http://works.bepress.com/hu-yang/20/