This manuscript addresses identification, analysis, formation and occurrence of key disinfection byproducts (DBPs) formed during chlorination and/or ozonation of both natural seawater (NSW), and synthetic high- and low-bromide saltwater (HBSW and LBSW, respectively). In this study, several groups of water disinfection byproducts were studied, including haloacetic acids (HAAs), halonitromethanes (HNMs), bromate and iodate. Three different water systems were studied including filtered natural seawater (NSW, ca. 64.9mgL-1 Br-), a high-bromide (Br-) saltwater (HBSW, ca. 24.8mgL-1 Br), and low-Br- saltwater (LBSW, ca. 4.3mgL-1Br). Because ozone reacts with Cl- to form free chlorine in seawater and salt water systems, similar DBP patterns were observed for both chlorine and ozone oxidants. the results revealed that some HAAs and HNMs are formed at greater than 100μgL-1 concentrations and are greatly affected by water constituents and formulations when treated with chlorine and ozone. the results showed that in low-Br- water salt water, chlorinated HAAs and HNMs predominated, while much greater concentrations of brominated HAAs and HNMs were produced in both natural and synthetic higher Br- saltwater. Concentrations of bromate and iodate were strongly impacted by factors other than Br- and I- concentrations including whether the system was open or closed.