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Article
Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
Nature Reviews Cancer (2002)
  • Hildegard M. Schuller, University of Tennessee, Knoxville
Abstract

Adenocarcinoma of the lungs and pancreas are among the most common and most deadly smoking-associated cancers. Cigarette smoke contains various toxic chemicals, including a carcinogenic nitrosamine, nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). One of the most well-known features of NNK is the ability of its metabolites to bind to DNA and induce activating point mutations in the RAS gene. But NNK is also a beta-adrenergic-receptor agonist that stimulates arachidonic acid release, leading to the formation of mitogenic metabolites that stimulate DNA synthesis and cell proliferation. NNK therefore contributes to tobacco-induced carcinogenesis by several mechanisms.

Keywords
  • smoking,
  • lung cancer,
  • adenocarcinoma,
  • pancreatic cancer
Publication Date
June, 2002
Citation Information
Hildegard M. Schuller. "Mechanisms of smoking-related lung and pancreatic adenocarcinoma development" Nature Reviews Cancer Vol. 2 Iss. 6 (2002)
Available at: http://works.bepress.com/hildegard_schuller/28/