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Article
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
Nature Reviews Cancer (2009)
  • Hildegard M. Schuller, University of Tennessee, Knoxville
Abstract

Nicotinic acetylcholine receptors (nAChRs) are the central regulators of stimulatory and inhibitory neurotransmitters that control the synthesis and release of growth, angiogenic and neurotrophic factors in cancer cells, the cancer microenvironment and distant organs. Data discussed in this Review suggests that smoking and possibly other environmental and lifestyle factors increase the function of nAChRs that stimulate cancer cells and reduce the function of nAChRs that inhibit cancer cells. This novel paradigm necessitates the development of marker-guided cancer intervention strategies that aim to restore the balance between nAChR-mediated stimulatory and inhibitory neurotransmitters and their downstream effectors. DOI: 10.1038/nrc2590

Keywords
  • cancer,
  • oncology,
  • nicotinic receptors
Publication Date
March, 2009
Citation Information
Hildegard M. Schuller. "Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?" Nature Reviews Cancer Vol. 9 (2009)
Available at: http://works.bepress.com/hildegard_schuller/23/