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Article
Oncogenesis and cancer stem cells: current opinions and future directions.
Journal of Cellular and Molecular Medicine (2009)
  • Xiaoyu Cheng, Australian National University
  • Helen C O'Neill, Australian National University
Abstract
There is increasing evidence to show that only a subset of cancer cells drives the growth and progression of a tumour. These cells share similar properties with normal stem cells and are termed 'cancer stem cells'. Cancer stem cells have been identified in acute myeloid leukaemia and in some solid tumours by their distinct expression of cell surface antigens. Their long-term, self-renewing capacity is thought to be a determining factor in the maintenance and regrowth of the tumour. Studies on haematopoietic cancers show that important signalling pathways and genes for normal haematopoiesis, such as Wnt, NF-kappaB, Notch, hedgehog (Hh) and Bmi1, are oncogenic, thereby potentially involved in cancer stem cell regulation. Elimination of cancer stem cells in tumours could result in the degeneration of downstream cells, which makes them potential targets for new cancer therapies.
Keywords
  • cancer stem cell,
  • haematopoietic stem cell,
  • acute myeloid leukaemia,
  • oncogenesis,
  • signalling pathways,
  • niche
Publication Date
2009
Publisher Statement
© 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
Citation Information
Xiaoyu Cheng and Helen C O'Neill. "Oncogenesis and cancer stem cells: current opinions and future directions." Journal of Cellular and Molecular Medicine Vol. 13 Iss. 11-12 (2009)
Available at: http://works.bepress.com/helen_oneill/39/