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Article
Concise review: Dendritic cell development in the context of the spleen microenvironment
Stem Cells (2007)
  • Jonathan K. H Tan, Australian National University
  • Helen C. O'Neill, Australian National University
Abstract
The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogenic or regulatory rather than immunostimulatory function is considered. Disclosure of potential conflicts of interest is found at the end of this article.
Keywords
  • Dendritic cell development,
  • spleen,
  • hematopoiesis,
  • niche,
  • microenvironment
Publication Date
2007
Publisher Statement
┬ęCopyright AlphaMed Press, 2007
Citation Information
Jonathan K. H Tan and Helen C. O'Neill. "Concise review: Dendritic cell development in the context of the spleen microenvironment" Stem Cells Vol. 25 Iss. 9 (2007)
Available at: http://works.bepress.com/helen_oneill/31/