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Spleen as a site for Hematopoiesis of a distinct antigen presenting cell type
Stem Cells International (2011)
  • Helen O'Neill, The Australian National University
  • Kristin Griffiths, The Australian National University
  • Pravin Periasamy, The Australian National University
  • Rebecca Hinton, The Australian National University
  • Ying-Ying Hey, The Australian National University
  • Sawang Petvises, The Australian National University
  • Jonathan Tan, The Australian National University
Abstract
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a distinct microenvironment for hematopoiesis of a novel myeloid cell arising from self-renewing hematopoietic stem cells (HSC) or progenitors endogenous to spleen.
Keywords
  • cell,
  • bone,
  • marrow,
  • differentiation,
  • cell,
  • lineage,
  • cell,
  • type
Publication Date
2011
Publisher Statement
© Copyright, The Authors , 2014 This work is licensed under a Creative Commons 4.0 License
Citation Information
Helen O'Neill, Kristin Griffiths, Pravin Periasamy, Rebecca Hinton, et al.. "Spleen as a site for Hematopoiesis of a distinct antigen presenting cell type" Stem Cells International (2011)
Available at: http://works.bepress.com/helen_oneill/22/