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Article
Murine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function
Journal of Cellular and Molecular Medicine (2012)
  • Yingying Hey, Australian National University
  • Helen O'Neill, Australian National University
Abstract
The spleen contains multiple subsets of myeloid and dendritic cells (DC). DC are important antigen presenting cells (APC) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naı¨ve T cells. However, DC are a heterogeneous population and each subset differs subtly in phenotype, function and location. Similarly, myeloid cell subsets can be distinguished which can also play an important role in the regulation of immunity. This review aims to characterize splenic subsets of DC and myeloid cells to better understand their individual roles in the immune response.
Keywords
  • dendritic,
  • cell,
  • myeloid,
  • antigen,
  • presentation
Publication Date
January 1, 2012
Publisher Statement
© Copyright, The Authors & Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd, 2012
Citation Information
Yingying Hey and Helen O'Neill. "Murine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function" Journal of Cellular and Molecular Medicine Vol. 16 Iss. 11 (2012)
Available at: http://works.bepress.com/helen_oneill/21/