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Investigation into the prevalence of a novel dendritic-like cell subset in vivo
Journal of Cellular and Molecular Medicine (2013)
  • Kristin Griffiths, Australian National University
  • Jonathan Tan, Australian National University
  • Helen O'Neill, Australian National University
Abstract
A novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8+ T cells. This paper shows the subset to be unique to spleen and blood, with a similar, but possibly functionally distinct subset also present in bone marrow. The prevalence of the subset is low; ~6% of all dendritic and myeloid cells in the spleen and ~5% in blood. However, they are a distinct cell type on the basis of marker expression, and endocytic and T-cell stimulatory capacity. Attempts to identify an enriched population of these cells in mutant mouse strains with reported increases in myelopoiesis showed either a lack of L-DC or an altered phenotype reflective of the phenotype of the mouse strain.
Keywords
  • Bone,
  • marrow,
  • Cross-presentation,
  • Dendritic,
  • cells,
  • Spleen
Publication Date
2013
Publisher Statement
© Copyright, The Authors , 2014 This work is licensed under a Creative Commons 4.0 License
Citation Information
Kristin Griffiths, Jonathan Tan and Helen O'Neill. "Investigation into the prevalence of a novel dendritic-like cell subset in vivo" Journal of Cellular and Molecular Medicine Vol. 17 Iss. 12 (2013)
Available at: http://works.bepress.com/helen_oneill/13/