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Novel splenic antigen presenting cell derive from a Lin-ckitlo progenitor
Journal of Leukocyte Biology (2013)
  • Pravin Periasamy, Australian National University
  • Jonanthan Tan, Australian National University
  • Helen O'Neill, Australian National University
The main DC subsets in murine spleen arise from BMderived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin-c-kitlo hematopoietic progenitor and is most highly enriched among the Lin-c-kitloCD34+ subset. Dendritic-like cells produced in vitro functionally resemble the previously described in vivo equivalent subset with high endocytic capacity and capability for antigen-specific activation of CD8+ T cells but not CD4+ T cells.
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Pravin Periasamy, Jonanthan Tan and Helen O'Neill. "Novel splenic antigen presenting cell derive from a Lin-ckitlo progenitor" Journal of Leukocyte Biology Vol. 93 Iss. 1 (2013)
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