Novel splenic antigen presenting cell derive from a Lin-ckitlo progenitorJournal of Leukocyte Biology (2013)
AbstractThe main DC subsets in murine spleen arise from BMderived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin-c-kitlo hematopoietic progenitor and is most highly enriched among the Lin-c-kitloCD34+ subset. Dendritic-like cells produced in vitro functionally resemble the previously described in vivo equivalent subset with high endocytic capacity and capability for antigen-specific activation of CD8+ T cells but not CD4+ T cells.
Citation InformationPravin Periasamy, Jonanthan Tan and Helen O'Neill. "Novel splenic antigen presenting cell derive from a Lin-ckitlo progenitor" Journal of Leukocyte Biology Vol. 93 Iss. 1 (2013)
Available at: http://works.bepress.com/helen_oneill/11/