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A Polymorphic DNA Marker Linked to Cystic Fibrosis is Located on Chromosome 7
Pre 1990
  • Robert G. Knowlton, Department of Human Genetics Collaborative Research, MA
  • Odile Cohen-Haguenauer, Unité de Recherches de Génétique Médicale (INSERM U12), Hôpital des Enfants Malades, France
  • Nguyen Van Cong, Unité de Recherches de Génétique Médicale (INSERM U12), Hôpital des Enfants Malades, France
  • Jean Frézal, Unité de Recherches de Génétique Médicale (INSERM U12), Hôpital des Enfants Malades, France
  • Valerie A. Brown, Department of Human Genetics Collaborative Research, MA
  • David F. Barker, Department of Human Genetics Collaborative Research, MA
  • Jeffrey C. Braman, Department of Human Genetics Collaborative Research, MA
  • James W. Schumm, Department of Human Genetics Collaborative Research, MA
  • Lap-Chee Tsui, University of Toronto
  • Manuel Buchwald, University of Toronto
  • Helen Donis-Keller, Franklin W. Olin College of Engineering
Document Type
Article
Publication Date
11-1-1985
Disciplines
Abstract
Although cystic fibrosis (CF) is among the most common inherited diseases in Caucasian populations, the basic biochemical defect is not yet known. CF is inherited as an autosomal recessive trait apparently due to mutations in a single gene, whence the efforts made to identify the genetic locus responsible by linkage studies. Two markers have recently been identified that are genetically linked to CF: one is a genetic variation in serum level of activity of the enzyme paraoxonase, and the other is a restriction fragment length polymorphism (RFLP) identified with a randomly isolated DNA probe. We report here that the genetic locus DOCRI-917 defined by the cloned DNA probe is located on chromosome 7.
Comments

© 1985 Nature Publishing Group. This article was published in Nature, vol. 318, iss. 6044, pages 380-382 and may be found here.

Citation Information
Robert G. Knowlton, Odile Cohen-Haguenauer, Nguyen Van Cong, Jean Frézal, et al.. "A Polymorphic DNA Marker Linked to Cystic Fibrosis is Located on Chromosome 7" (1985)
Available at: http://works.bepress.com/helen_donis-keller/33/