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Adaptation to Lysozyme Does Not Occur Via Receptor-Mediated Endocytosis in Tetrahymena thermophila
WWW Journal of Biology
  • Joseph M. Cantor
  • Stephanie R. Mace
  • Coriann M. Kooy
  • Brian D. Caldwell
  • Heather G. Kuruvilla, Cedarville University
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Publication Date
The free-swimming ciliate, Tetrahymena thermophila, exhibits avoidance behavior when exposed to chemorepellent compounds, such as lysozyme. Cells fail to respond to lysozyme after prolonged exposure (10-14 minutes), a phenomenon known as adaptation. The mechanism of chemosensory adaptation in this ciliate is unknown. The lysozyme receptor has been affinity purified from Tetrahymena and a polyclonal antibody has been generated to the receptor. This antibody was used to immunolocalize the receptor on the cell membrane of Tetrahymena. Lysozyme-adapted cells showed a similar staining pattern to non-adapted cells. These data indicate that receptor-mediated endocytosis is not the primary mechanism for lysozyme adaptation in T. thermophila.
  • adaptation,
  • chemorepellent,
  • receptor-mediated endocytosis
Citation Information
Cantor, J. M., Mace, S. R., M, K. C. , Caldwell, B. D. , & Kuruvilla, H. G. (1999). Adaptation to lysozyme does not occur via receptor-mediated endocytosis in Tetrahymena thermophila. WWW Journal of Biology, 4, 4-6.