Honors and Awards
- Faculty Scholar Award, Cedarville University - 2007
- Technology Incentive Award, Cedarville University - 1999, 2000
- Faculty Excellence in Teaching Award, Southwestern Ohio Council for Higher Education - 2005
- Faculty Teaching Effectiveness Award, Cedarville University - 2004
- Excellence in Education Award, Ohio Magazine - 2003
- Cell Biology
- Advanced Cell Biology
- Signal Transduction
- Biological Research
|B.S., Houghton College|
|Ph.D., SUNY University at Buffalo|
Department of Science and Mathematics
Purification and Characterization of a Novel Lysozyme Receptor from Tetrahymena Thermophila Faculty Dissertations (1997)
Chemosensory transduction is an important function in cells ranging from prokaryotes to differentiated eukaryotic tissues such as neurons. The functions of chemoreception are quite diverse, vary in accordance with cell type, and range from finding ...
Refereed Journal Articles (19)
Characterization of a Netrin-1-like Protein Secreted by Tetrahymena thermophila Current Trends in Microbiology (2017)
Netrins are a family of pleiotropic signaling proteins, expressed throughout the animal kingdom, that have guidance functions in the development of the nervous system and other branched tissues, Netrins often serve a chemotactic role, acting ...
Netrin-1 Peptide Is a Chemorepellent in Tetrahymena thermophila International Journal of Peptides (2016)
Netrin-1 is a highly conserved, pleiotropic signaling molecule that can serve as a neuronal chemorepellent during vertebrate development. In vertebrates, chemorepellent signaling is mediated through the tyrosine kinase, src-1, and the tyrosine phosphatase, shp-2. Tetrahymena ...
Nociceptin Signaling Involves a Calcium-Based Depolarization in Tetrahymena thermophila International Journal of Peptides (2013)
Tetrahymena thermophila are free-living, ciliated eukaryotes. Their behavioral response to stimuli is well characterized and easily observable, since cells swim toward chemoattractants and avoid chemorepellents. Chemoattractant responses involve increased swim speed or a decreased change ...
GTP Avoidance in Tetrahymena thermophila Requires Tyrosine Kinase Activity, Intracellular Calcium, NOS, and Guanylyl Cyclase Purinergic Signalling (2008)
Guanosine 5'-triphosphate (GTP) is a chemorepellent in Tetrahymena thermophila that has been shown to stimulate cell division as well as ciliary reversal. Previous studies have proposed that GTP avoidance is linked to a receptor-mediated, calcium-based ...
A Comparison of the Polycation Receptors of Paramecium tetraurelia and Tetrahymena thermophila The Journal of Eukaryotic Microbiology (2008)
Chemorepellents are compounds that cause ciliated protozoans to reorient their swimming direction. A number of chemorepellents have been studied in the ciliated protozoans, Paramecium and Tetrahymena. Chemorepellents, such as polycations, cause the organism to exhibit ...
PACAP-38 Signaling in Tetrahymena thermophila Involves NO and cGMP Acta Protozoologica (2004)
Chemorepellents are signaling molecules, which have been shown to be important for mammalian neuronal development, and are presumed to have a role in protozoan defense. Tetrahymena thermophila represent a good model system in which to ...
Biochemical Evidence for a P2Y-like Receptor in Tetrahymena thermophila Journal of Comparative Physiology A (2003)
Extracellular nucleotides are ubiquitous signaling molecules. ATP signals through two receptor types: the ionotropic P2X receptors, and the metabotropic P2Y receptors. ATP acts as a chemorepellent in Tetrahymena thermophila, where it causes a distinct avoidance ...
Pharmacological Evidence Suggests That the Lysozyme/PACAP Receptor of Tetrahymena thermophila is a Polycation Receptor A cta Protozoologica (2003)
Pituitary adenylate cyclase activating polypeptide (PACAP) is a peptide hormone that exists in two biologically active forms: PACAP-38 and PACAP-27. Several types of PACAP receptors have been characterized, and these have been classified into three ...
Chemorepellent Signaling Through the Lysozyme/PACAP Receptor Is Mediated Through cAMP and PKC in Tetrahymena thermophila Journal of Comparative Physiology A (2001)
Pituitary adenylate cyclase-activating peptide and lysozyme are potent chemorepellents which act through the same receptor in Tetrahymena. Using in vivo behavioral studies, we have found that the pituitary adenylate cyclase-activating peptide /lysozyme receptor appears to ...
PACAP-38 Is a Chemorepellent and an Agonist for the Lysozyme Receptor in Tetrahymena thermophila Journal of Comparative Physiology A (2000)
Pituitary adenylate cyclase activating peptide (PACAP-38) is a peptide hormone which functions in many mammalian systems, including the nervous and digestive systems. Using in vivo behavioral studies, we have found that this hormone functions as ...
Adaptation to Lysozyme Does Not Occur Via Receptor-Mediated Endocytosis in Tetrahymena thermophila WWW Journal of Biology (1999)
The free-swimming ciliate, Tetrahymena thermophila, exhibits avoidance behavior when exposed to chemorepellent compounds, such as lysozyme. Cells fail to respond to lysozyme after prolonged exposure (10-14 minutes), a phenomenon known as adaptation. The mechanism of ...
Chemosensory Responses of Tetrahymena thermophila to CB2, a 24 Amino Acid Fragment of Lysozyme Journal of Comparative Physiology A (1999)
While lysozyme is a depolarizing chemorepellent in Tetrahymena, the entire lysozyme molecule is not necessary to activate the lysozyme receptor. Reduced lysozyme was cut into three fragments by cyanogen bromide cleavage and the fragments (CB1, ...
ATP Reception and Chemosensory Adaptation in Tetrahymena thermophila Journal of Experimental Biology (1999)
Micromolar concentrations of adenosine triphosphate (ATP) and its non-hydrolyzable analog β- γ -methylene ATP are both effective depolarizing chemorepellents in Tetrahymena thermophila. Chemorepellent behavior consists of repeated bouts of backward swimming (avoidance reactions) that can ...
Chemosensory Adaptation to Lysozyme and GTP Involves Independently Regulated Receptors in Tetrahymena thermophila Journal of Eukaryotic Microbiology (1997)
Chemosensory adaptation is seen in Tetrahymena thermophila following prolonged exposure (ten minutes) to micromolar concentrations of the chemorepellents lysozyme or guanosine triphosphate (GTP). Since these cells initially show repeated backward swimming episodes (avoidance reactions) in ...
Autonomy and Patient Care: To What Extent Should Children Make Their Own Decisions? Bioethics in Faith and Practice
On June 14, 2016, 5-year old Julianna Snow died at home, in accordance with her stated wishes not to return to the hospital. Julianna suffered from a severe form of Charcot-Marie-Tooth disease, an inherited neurodegenerative ...