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Heather Wheeler

Associate Professor

Works
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About Heather Wheeler

Present	Professor, Loyola University Chicago ‐ Department of Biology
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Biology and Computer Sciences

Genome-wide analyses of the past few years have revealed that a substantial portion of the genetic control of complex traits is exerted through the regulation of gene expression. Much of the genetic variation associated with complex traits falls outside the protein coding regions of genes. Mechanistic understanding of how this variation contributes to phenotype is lacking, but gene regulation is thought to play a major role. We develop and apply methods that fully harness gene regulation within complex trait association and prediction studies.

http://orcid.org/0000-0003-1365-9667

Article

Protein prediction for trait mapping in diverse populations

PLOS ONE (2022)

Heather Wheeler, Ryan Schubert, Elyse Geoffroy, Isabelle Gregga, et al.

Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of ...

OpenURL

Article

Population Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate

iScience (2020)

Elyse Geoffroy, Isabelle Gregga and Heather E. Wheeler

Link

Article

Polygenic transcriptome risk scores improve portability of polygenic risk scores ...

bioRxiv (2020)

Liang Y, Pividori M, Manichaikul A, Palmer Aa, et al.

Link

Article

Comparing local ancestry inference models in populations of two- and ...

PeerJ (2020)

Ryan Schubert, Angela Andaleon and Heather E. Wheeler

Link

Article

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in ...

Clinical Cancer Research (2020)

Matthew R. Trendowski, Heather E. Wheeler, Omar El-Charif, Darren R. Feldman, et al.

Link

Article

Multi-ethnic transcriptome-wide association study of prostate cancer.

PLOS ONE (2020)

Peter N Fiorica, Ryan Schubert, John D Morris, Mohammed Abdul Sami, et al.

Link

Article

Fine-mapping and QTL tissue-sharing information improves the reliability of causal ...

Genetic Epidemiology (2020)

Alvaro N. Barbeira, Owen J. Melia, Yanyu Liang, Rodrigo Bonazzola, et al.

Link

Article

Transcriptome-Wide Association Studies Identify Novel Genes Associated with Chemotherapy Toxicity ...

F1000Research (2020)

Ashley Mulford, Claudia Wing, M Eileen Dolan and Heather E Wheeler

Link

Article

Clinical and genetic risk factors for radiation-associated ototoxicity: A report ...

Journal of Clinical Oncology (2020)

Matthew R. Trendowski, Jessica Baedke, Yadav Sapkota, Omar El Charif, et al.

Link

Article

Genetic regulatory variation in populations informs transcriptome analysis in rare ...

Science (2019)

Pejman Mohammadi, Stephane E Castel, Beryl B Cummings, Jonah Einson, et al.

Transcriptome data can facilitate the interpretation of the effects of rare genetic variants. Here, we introduce ANEVA (analysis of expression ...

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Article

Cross-population Transcriptome Prediction Models for Transcriptome-Wide Association Studies in Diverse ...

Undergraduate Research and Engagement Symposium

Christopher Nguyen, Dr. Heather Wheeler and Daniel Araujo

Genome-wide association studies (GWAS) have been utilized to find associations between single nucleotide polymorphisms (SNPs) and traits. However, most GWAS ...

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Article

Cross-population Transcriptome Prediction Models for Transcriptome-Wide Association Studies in Diverse ...

Undergraduate Research and Engagement Symposium

Christopher Nguyen, Dr. Heather Wheeler and Daniel Araujo

Genome-wide association studies (GWAS) have been utilized to find associations between single nucleotide polymorphisms (SNPs) and traits. However, most GWAS ...

Download

Article

Determining the Genetic Component of Protein Levels with TWAS

Undergraduate Research and Engagement Symposium

Henry Wittich and Heather Wheeler

The central dogma of biology describes how DNA serves as the blueprint for life; genes encoded in DNA get transcribed ...

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Article

Determining the Genetic Component of Protein Levels with TWAS

Undergraduate Research and Engagement Symposium

Henry Wittich and Heather Wheeler

The central dogma of biology describes how DNA serves as the blueprint for life; genes encoded in DNA get transcribed ...

Download

Article

Performing Proteome, Genome, and Transcriptome Studies for Creatinine Clearance

Undergraduate Research and Engagement Symposium

Rhea Prag and Heather Wheeler

Precision medicine allows treatments to be personalized to the person based on their genome. However, the majority of the studies ...

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Article

Performing Proteome, Genome, and Transcriptome Studies for Creatinine Clearance

Undergraduate Research and Engagement Symposium

Rhea Prag and Heather Wheeler

Precision medicine allows treatments to be personalized to the person based on their genome. However, the majority of the studies ...

Download

Article

Performing Proteome, Genome, and Transcriptome Studies for Creatinine Clearance

Undergraduate Research and Engagement Symposium

Rhea Prag and Heather Wheeler

Precision medicine allows treatments to be personalized to the person based on their genome. However, the majority of the studies ...

Download

Article

Proteome Association Studies for Cancer

Undergraduate Research and Engagement Symposium

Isabelle Gregga and Heather Wheeler

Genome-wide association studies (GWAS) have been used in cancer research in the last two decades, contributing to significant advances in ...

Download

Article

Proteome Association Studies for Cancer

Undergraduate Research and Engagement Symposium

Isabelle Gregga and Heather Wheeler

Genome-wide association studies (GWAS) have been used in cancer research in the last two decades, contributing to significant advances in ...

Download

Article

Proteome Association Studies for Cancer

Undergraduate Research and Engagement Symposium

Isabelle Gregga and Heather Wheeler

Genome-wide association studies (GWAS) have been used in cancer research in the last two decades, contributing to significant advances in ...

Download

Article

Proteome Association Studies in Populations of Diverse Ancestries

Undergraduate Research and Engagement Symposium

Isabelle Gregga, Elyse Geoffroy, Ryan Schubert and Heather Wheeler

Most GWAS have been conducted in populations of European ancestries, but these results do not reflect the global population or ...

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Article

Chronic circadian misalignment results in reduced longevity and large-scale changes ...

BMC Genomics (2019)

Alex C. Boomgarden, Gabriel D. Sagewalker, Aashaka C. Shah, Sarah D. Haider, et al.

Link

Article

Genetic regulatory variation in populations informs transcriptome analysis in rare ...

Science (2019)

Pejman Mohammadi, Stephane E Castel, Beryl B Cummings, Jonah Einson, et al.

Transcriptome data can facilitate the interpretation of the effects of rare genetic variants. Here, we introduce ANEVA (analysis of expression ...

Download

Article

Genetic regulatory variation in populations informs transcriptome analysis in rare ...

Science (2019)

Pejman Mohammadi, Stephane E Castel, Beryl B Cummings, Jonah Einson, et al.

Transcriptome data can facilitate the interpretation of the effects of rare genetic variants. Here, we introduce ANEVA (analysis of expression ...

Download

Article

Transcriptome association studies of neuropsychiatric traits in African Americans implicate ...

PeerJ (2019)

Peter N. Fiorica and Heather E. Wheeler

Link

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