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Heather Wheeler

Associate Professor

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About Heather Wheeler

Present	Professor, Loyola University Chicago ‐ Department of Biology
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Biology and Computer Sciences

Genome-wide analyses of the past few years have revealed that a substantial portion of the genetic control of complex traits is exerted through the regulation of gene expression. Much of the genetic variation associated with complex traits falls outside the protein coding regions of genes. Mechanistic understanding of how this variation contributes to phenotype is lacking, but gene regulation is thought to play a major role. We develop and apply methods that fully harness gene regulation within complex trait association and prediction studies.

http://orcid.org/0000-0003-1365-9667

Article

Multivariate Adaptive Shrinkage Improves Cross-Population Transcriptome Prediction and Association Studies ...

Human Genetics and Genomics Advances (2023)

Daniel Araujo, Chris Nguyen, Xiaowei Hu, Anna V. Mikhaylova, et al.

Transcriptome prediction models built with data from European-descent individuals are less accurate when applied to different populations because of differences ...

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Article

Predicted Proteome Association Studies of Breast, Prostate, Ovarian, and Endometrial ...

Cancer Epidemiology, Biomarkers & Prevention (2023)

Isabelle Gregga, Paul D. P. Pharoah, Simon A. A. Gayther, Manichaikul A, et al.

Predicting protein levels from genotypes for proteome-wide association studies (PWAS) may provide insight into the mechanisms underlying cancer susceptibility.

OpenURL

Article

Transcriptome-wide association study of the plasma proteome reveals cis and ...

American Journal of Human Genetics (2023)

Henry Wittich, Kristin G Ardlie, Kent D. Taylor, Peter Durda, et al.

Regulation of transcription and translation are mechanisms through which genetic variants affect complex traits. Expression quantitative trait locus (eQTL) studies ...

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Article

Genetic and environmental variation impact transferability of polygenic risk scores

Cell Reports Medicine (2022)

Daniel S. Araújo and Heather E. Wheeler

Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental ...

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Article

Protein prediction for trait mapping in diverse populations

PLOS ONE (2022)

Heather Wheeler, Ryan Schubert, Elyse Geoffroy, Isabelle Gregga, et al.

Genetically regulated gene expression has helped elucidate the biological mechanisms underlying complex traits. Improved high-throughput technology allows similar interrogation of ...

OpenURL

Article

Transcriptome Prediction Performance Across Machine Learning Models and Diverse Ancestries

HGG Advances (2021)

Paul Chukwuebuka Okoro, Ryan Schubert, Xiuqing Guo, W. Craig Johnson, et al.

Transcriptome prediction methods such as PrediXcan and FUSION have become popular in complex trait mapping. Most transcriptome prediction models have ...

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Article

Population Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate

iScience (2020)

Elyse Geoffroy, Isabelle Gregga and Heather E. Wheeler

Link

Article

Polygenic transcriptome risk scores improve portability of polygenic risk scores ...

bioRxiv (2020)

Liang Y, Pividori M, Manichaikul A, Palmer Aa, et al.

Link

Article

Comparing local ancestry inference models in populations of two- and ...

PeerJ (2020)

Ryan Schubert, Angela Andaleon and Heather E. Wheeler

Link

Article

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in ...

Clinical Cancer Research (2020)

Matthew R. Trendowski, Heather E. Wheeler, Omar El-Charif, Darren R. Feldman, et al.

Link

Article

Multi-ethnic transcriptome-wide association study of prostate cancer.

PLOS ONE (2020)

Peter N Fiorica, Ryan Schubert, John D Morris, Mohammed Abdul Sami, et al.

Link

Article

Fine-mapping and QTL tissue-sharing information improves the reliability of causal ...

Genetic Epidemiology (2020)

Alvaro N. Barbeira, Owen J. Melia, Yanyu Liang, Rodrigo Bonazzola, et al.

Link

Article

Transcriptome-Wide Association Studies Identify Novel Genes Associated with Chemotherapy Toxicity ...

F1000Research (2020)

Ashley Mulford, Claudia Wing, M Eileen Dolan and Heather E Wheeler

Link

Article

Clinical and genetic risk factors for radiation-associated ototoxicity: A report ...

Journal of Clinical Oncology (2020)

Matthew R. Trendowski, Jessica Baedke, Yadav Sapkota, Omar El Charif, et al.

Link

Article

Genetic regulatory variation in populations informs transcriptome analysis in rare ...

Science (2019)

Pejman Mohammadi, Stephane E Castel, Beryl B Cummings, Jonah Einson, et al.

Transcriptome data can facilitate the interpretation of the effects of rare genetic variants. Here, we introduce ANEVA (analysis of expression ...

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Article

Cross-population Transcriptome Prediction Models for Transcriptome-Wide Association Studies in Diverse ...

Undergraduate Research and Engagement Symposium

Christopher Nguyen, Dr. Heather Wheeler and Daniel Araujo

Genome-wide association studies (GWAS) have been utilized to find associations between single nucleotide polymorphisms (SNPs) and traits. However, most GWAS ...

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Article

Cross-population Transcriptome Prediction Models for Transcriptome-Wide Association Studies in Diverse ...

Undergraduate Research and Engagement Symposium

Christopher Nguyen, Dr. Heather Wheeler and Daniel Araujo

Genome-wide association studies (GWAS) have been utilized to find associations between single nucleotide polymorphisms (SNPs) and traits. However, most GWAS ...

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Article

Determining the Genetic Component of Protein Levels with TWAS

Undergraduate Research and Engagement Symposium

Henry Wittich and Heather Wheeler

The central dogma of biology describes how DNA serves as the blueprint for life; genes encoded in DNA get transcribed ...

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Article

Determining the Genetic Component of Protein Levels with TWAS

Undergraduate Research and Engagement Symposium

Henry Wittich and Heather Wheeler

The central dogma of biology describes how DNA serves as the blueprint for life; genes encoded in DNA get transcribed ...

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Article

Performing Proteome, Genome, and Transcriptome Studies for Creatinine Clearance

Undergraduate Research and Engagement Symposium

Rhea Prag and Heather Wheeler

Precision medicine allows treatments to be personalized to the person based on their genome. However, the majority of the studies ...

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Article

Performing Proteome, Genome, and Transcriptome Studies for Creatinine Clearance

Undergraduate Research and Engagement Symposium

Rhea Prag and Heather Wheeler

Precision medicine allows treatments to be personalized to the person based on their genome. However, the majority of the studies ...

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Article

Performing Proteome, Genome, and Transcriptome Studies for Creatinine Clearance

Undergraduate Research and Engagement Symposium

Rhea Prag and Heather Wheeler

Precision medicine allows treatments to be personalized to the person based on their genome. However, the majority of the studies ...

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Article

Proteome Association Studies for Cancer

Undergraduate Research and Engagement Symposium

Isabelle Gregga and Heather Wheeler

Genome-wide association studies (GWAS) have been used in cancer research in the last two decades, contributing to significant advances in ...

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Article

Proteome Association Studies for Cancer

Undergraduate Research and Engagement Symposium

Isabelle Gregga and Heather Wheeler

Genome-wide association studies (GWAS) have been used in cancer research in the last two decades, contributing to significant advances in ...

Download

Article

Proteome Association Studies for Cancer

Undergraduate Research and Engagement Symposium

Isabelle Gregga and Heather Wheeler

Genome-wide association studies (GWAS) have been used in cancer research in the last two decades, contributing to significant advances in ...

Download

About Heather Wheeler

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Featured Works (6)

Recent Works (20)