Medication adherence is an issue plaguing multiple populations such as the elderly or hard to reach populations such as those with HIV. Medication reminders are often employed to improve medication observance. Literature demonstrates that generic reminders are ineffective and often ignored. This study illustrates how to build a custom medication reminder system to determine the effect and impact of customized medication message reminders over generic reminder messages. Results show customized messages are statistically favored over generic messages. This work serves as an important step toward customized medication reminders to improve medication compliance.