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dGlucose is Related to Renal Function Changes in Diabetes
Diabetes Research and Clinical Practice
  • Anil K. Mandal
  • Linda M. Hiebert
  • Harry J. Khamis, Wright State University - Main Campus
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Aims: This study examines if dglucose, two-hour postprandial (2hPP) minus fasting glucose (F), predicts glycemic control better than F or 2hPPglucose.

Methods: F and 2hPPglucose, and renal function variables; BUN, serum creatinine (Scr), and estimated GFR (eGFR), were obtained from 56 insulin treated diabetic adults. 2hPP–F(d) was calculated. Variables were compared when 2hPPglucose was <200 (n = 23) or >200 mg/dL (n = 33). Correlation coefficients were calculated for F, 2hPP or 2hPP–F(d) renal function variables versus those for glucose.

Results: Variables differed significantly between F and 2hPP (t-test, p < 0.05) for all patients and when 2hPPglucose was < or >200 mg/dL, except dBUN at <200 mg/dL. When F, 2hPP or 2hPP–F(d) variables between 2hPPglucose < and >200 mg/dL were compared, dScr was significant (p = 0.0327). Correlation coefficients between dglucose and dScr or deGFR, were significant for all patients (r = 0.420, p = 0.0013, and r = −0.434,p = 0.0008, respectively) and for 2hPPglucose >200 mg/dL (r = 0.523, p = 0.0018 and r = −0.513, p = 0.0023, respectively) but not 2hPPglucose <200 mg/dL. When dglucose increased by 100 mg/dL, dScr increased by 0.08 and 0.11 mg/dL, and deGFR decreased by 2.73 and 3.73 mL/min for all patients and >200 mg/dL, respectively.

Conclusions: dGlucose better predicts renal function changes than F or 2hPPglucose. Postprandial hyperglycemia (<200 mg/dL) control is crucial for renal protection in diabetes.

Citation Information
Anil K. Mandal, Linda M. Hiebert and Harry J. Khamis. "dGlucose is Related to Renal Function Changes in Diabetes" Diabetes Research and Clinical Practice Vol. 91 Iss. 2 (2011) p. 190 - 194 ISSN: 0168-8227
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