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Comorbidity Profiles and Inpatient Outcomes During Hospitalization for Heart Failure: An Analysis of the U.S. Nationwide Inpatient Sample
BMC Cardiovascular Disorders
  • Christopher S. Lee, Oregon Health & Science University
  • Christopher V. Chien, Oregon Health & Science University
  • Julie T. Bidwell, Oregon Health & Science University
  • Jill M. Gelow, Oregon Health & Science University
  • Quin E. Denfeld, Oregon Health & Science University
  • Ruth Masterson Creber, University of Pennsylvania
  • Harleah G. Buck, University of Pennsylvania
  • James O. Mudd, Oregon Health & Science University
Document Type
Publication Date
  • Heart failure,
  • Comorbidity,
  • Outcomes,
  • Inpatient
Digital Object Identifier (DOI)
Background Treatment of heart failure (HF) is particularly complex in the presence of comorbidities. We sought to identify and associate comorbidity profiles with inpatient outcomes during HF hospitalizations. Methods Latent mixture modeling was used to identify common profiles of comorbidities during adult hospitalizations for HF from the 2009 Nationwide Inpatient Sample (n = 192,327). Results Most discharges were characterized by "common" comorbidities. A "lifestyle" profile was characterized by a high prevalence of uncomplicated diabetes, hypertension, chronic pulmonary disorders and obesity. A "renal" profile had the highest prevalence of renal disease, complicated diabetes, and fluid and electrolyte imbalances. A "neurovascular" profile represented the highest prevalence of cerebrovascular disease, paralysis, myocardial infarction and peripheral vascular disease. Relative to the common profile, the lifestyle profile was associated with a 15% longer length of stay (LOS) and 12% greater cost, the renal profile was associated with a 30% higher risk of death, 27% longer LOS and 24% greater cost, and the neurovascular profile was associated with a 45% higher risk of death, 34% longer LOS and 37% greater cost (all p < 0.001). Conclusions Comorbidity profiles are helpful in identifying adults at higher risk of death, longer length of stay, and accumulating greater costs during hospitalizations for HF.
This article was written while the author, Harleah G. Buck, was at a previous institution.
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Creative Commons Attribution 4.0
Citation / Publisher Attribution

BMC Cardiovascular Disorders, v. 14, article 73, p. 1-9.

Citation Information
Christopher S. Lee, Christopher V. Chien, Julie T. Bidwell, Jill M. Gelow, et al.. "Comorbidity Profiles and Inpatient Outcomes During Hospitalization for Heart Failure: An Analysis of the U.S. Nationwide Inpatient Sample" BMC Cardiovascular Disorders Vol. 14 (2014) p. 1 - 9
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