Electrostatic potential surfaces of 5-HT3R agonists suggest accessory cation-p site adjacent to agonist binding domainBioorganic and Medicinal Chemistry Letters
AbstractElectrostatic potential surface mapping of various aromatic ring systems contained in 5-HT3R agonists indicate that some agonists contain an aromatic moiety capable of a favorable cation-p interaction next to the e-face of pyridine (or its bioisostere). A pharmacophore model has been proposed based on superimposition of two distinct 'aryl' interactions.
Citation InformationHarish S. Parihar and Karen S. Kirschbaum. "Electrostatic potential surfaces of 5-HT3R agonists suggest accessory cation-p site adjacent to agonist binding domain" Bioorganic and Medicinal Chemistry Letters Vol. 12 Iss. 19 (2002) p. 2743 - 2747
Available at: http://works.bepress.com/harish_parihar/6/