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Article
Electrostatic potential surfaces of 5-HT3R agonists suggest accessory cation-p site adjacent to agonist binding domain
Bioorganic and Medicinal Chemistry Letters
  • Harish S. Parihar, Philadelphia College of Osteopathic Medicine
  • Karen S. Kirschbaum
Document Type
Article
Publication Date
1-1-2002
Abstract

Electrostatic potential surface mapping of various aromatic ring systems contained in 5-HT3R agonists indicate that some agonists contain an aromatic moiety capable of a favorable cation-p interaction next to the e-face of pyridine (or its bioisostere). A pharmacophore model has been proposed based on superimposition of two distinct 'aryl' interactions.

Comments

This article was published in Bioorganic and Medicinal Chemistry Letters, Volume 12, Issue 19, Pages 2743-2747.

The published version is available at http://dx.doi.org/10.1016/S0960-894X(02)00514-0.

Copyright © 2002 Elsevier.

Citation Information
Harish S. Parihar and Karen S. Kirschbaum. "Electrostatic potential surfaces of 5-HT3R agonists suggest accessory cation-p site adjacent to agonist binding domain" Bioorganic and Medicinal Chemistry Letters Vol. 12 Iss. 19 (2002) p. 2743 - 2747
Available at: http://works.bepress.com/harish_parihar/6/