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Article
5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions
Bioorganic and Medicinal Chemistry Letters
  • Harish S. Parihar, Philadelphia College of Osteopathic Medicine
  • Asha Suryanarayanan
  • Chun Ma
  • Prasad Joshi
  • Padma Venkataraman
  • Marvin K. Schulte
  • Karen S. Kirschbaum
Document Type
Article
Publication Date
1-1-2001
Abstract

The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5-HT3R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N-benzyl group, resulted in the discovery of a partial agonist.

Comments

This article was published in Bioorganic and Medicinal Chemistry Letters, Volume 11, Issue 16, Pages 2133-2136.

The published version is available at http://dx.doi.org/10.1016/S0960-894X(01)00417-6.

Copyright © 2001 Elsevier.

Citation Information
Harish S. Parihar, Asha Suryanarayanan, Chun Ma, Prasad Joshi, et al.. "5-HT3R binding of lerisetron: An interdisciplinary approach to drug-receptor interactions" Bioorganic and Medicinal Chemistry Letters Vol. 11 Iss. 16 (2001) p. 2133 - 2136
Available at: http://works.bepress.com/harish_parihar/11/