In this research, we report a simple, versatile, and reproducible method for the synthesis of copper oxide nanoparticles via microwave assisted synthesis approach. The important advantage of this catalyst is due to its important role not only in the low temperature oxidation of CO but also in potential applications in pharmaceutical and fine chemical synthesis. The results reveal that the copper oxide catalyst has particularly a remarkable high activity for CO oxidation catalysis as it was found that copper oxide (CuO) catalyst has 100% conversion of carbon monoxide into carbon dioxide at 175 oC. This also could be attributed to the high degree of dispersion of the copper oxide nanoparticles with a particle size of 25-35 nm. Those nanoparticles were characterized by various spectroscopic techniques including; X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and transmission electron microscopy (TEM).