In this study, the hydroxyapatite powder is investigated for both of methylene blue and thymol blue in aqueous solution. The physical and chemical properties of the adsorbent were evaluated systematically using the different techniques including Microsoft Excel programming, linear regression model and also the coefficient of determination. Batch adsorption experiments were conducted to determine the effect of contact time, solution pH, initial dye concentrations, and also the adsorbent dosage on adsorption. The adsorption kinetic parameters confirmed the better fitting of pseudo-second order kinetic model for both of methylene blue and thymol blue. The isotherm data of methylene blue and thymol blue could be well described by the Freundlich isotherm model which means the adsorption is multilayer adsorption with non-uniform distribution of adsorption heat and affinities over the heterogeneous surface. The maximum adsorption capacity (KF) of methylene blue and thymol blue is found to be 0.2736 (L/mg) and 11.18407 (L/mg) respectively. The high specific surface area and the porous structure with some acidic functional groups on the surface were obviously responsible for high dyes adsorption onto hydroxyapatite (HA). Adsorption kinetics data were modeled with the application of Pseudo first order, Pseudo second order and Intraparticle diffusion models. The results revealed that the Pseudo second order model was the best fitting model. Which means that, the adsorption mechanism followed two stages in which the first one was fast and the other was slower step. Which means the adsorption of dye molecules was limited by intra particle diffusion and film diffusion, as well as the adsorption rate in both of adsorption system are depends only on the slower step. The Boyd plot exposed that the intra-particle diffusion was the rate controlling step of the adsorption process of both of methylene blue and thymol blue molecules by HA powder. However, the adsorption of methylene blue molecules (basic solution) using of HA as adsorbent particles is found to be extremely preferable than thymol blue molecules.