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Association of Traditional Chinese Medicine Therapy and the Risk of Dementia in Patients with Hypertension: A Nationwide Population-based Cohort Study
BMC Complementary and Alternative Medicine
  • Kuen-Hau Chen, Dalin Tzuchi Hospital
  • Ming-Hsien Yeh, Dalin Tzuchi Hospital
  • Hanoch Livneh, Portland State University
  • Bor-Chyuan Chen, Dalin Tzuchi Hospital
  • I-Hsin Lin, Tzu Chi University
  • Ming-Chi Lu, The Buddhist Tzuchi Medical Foundation
  • Tzung-Yi Tsai, National Cheng Kung University
  • Chia-Chou Yeh, Dalin Tzuchi Hospital
Document Type
Article
Publication Date
1-1-2017
Subjects
  • Chinese medicine -- Effect on patients with dementia,
  • Dementia -- Risk factors,
  • Hypertension -- Alternative treatment
Abstract
Background: Patients with hypertension (HTN) reportedly have a higher risk of developing dementia. However, it remains unclear if use of Traditional Chinese Medicine (TCM), the most common form of complementary and alternative medicine, can help lower the risk of dementia for these patients. So the aim of the study was to investigate the effects of TCM on dementia risk among patients with hypertension. Methods: This longitudinal cohort study used the Taiwanese National Health Insurance Research Database (NHIRD) to identify 143,382 newly diagnosed hypertension patients aged 20–90 years who received treatment between 1998 and 2007. Among them, 52,365 (36.52%) had received TCM after the onset of hypertension (TCM users), and the remaining 91,017 patients (63.48%) were designated as a control group (non-TCM users). All enrollees were followed until the end of 2012 to record the incidence of dementia. A Cox proportional hazards regression model was used to compute the hazard ratio (HR) of dementia in patients who received TCM. Results: During the 15-year follow-up, 3933 TCM users and 10,316 non-TCM users developed dementia, representing an incidence rate of 8.41 and 11.55%, respectively, per 1000 person-years. TCM users had a significantly reduced risk of dementia compared to non-TCM users (adjusted HR = 0.76; 95% confidence interval [CI] = 0.74–0.81). The predominant effect was observed among those treated with TCM longer than 180 days (adjusted HR = 0.65; 95% CI = 0.62–0.69). Among the commonly used TCM products, Tian-Ma-Gou-Teng-Yin, Dan-Shen (Radix Salviae Miltiorrhizae), Chuan-Niu-Xi (Radix Cyathulae), Ge-Gen (Radix Puerariae), Jia-Wei-Xiao-Yao-San, and Jue-Ming-Zi (Semen Cassiae) were significantly associated with a lower risk of dementia. Conclusions: Results from this population-based study support the effects of TCM on reducing dementia risk, which may provide a reference for dementia prevention strategies.
Description

© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

DOI
10.1186/s12906-017-1677-4
Persistent Identifier
http://archives.pdx.edu/ds/psu/20164
Citation Information
Chen, K. H., Yeh, M. H., Livneh, H., Chen, B. C., Lin, I. H., Lu, M. C., ... & Yeh, C. C. (2017). Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study. BMC complementary and alternative medicine, 17(1), 178.