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Article
Release of curcum inincorporated in albumin loaded silica
Malaysian Journal of Fundamental and Applied Sciences (2018)
  • Shafiyah Pondi, University Technology Malaysia
  • Wai Loon Leaw, University Technology Malaysia
  • Sheela Chandren, University Technology Malaysia
  • Hadi Nur, University Technology Malaysia
Abstract
In this work, we have prepared a new drug delivery system consisting of silica (SiO2) as the main carrier, while albumin acted as the co–carrier in order to control the release of drug. The system was prepared by simple wet chemical method. The efficiency of the designed system was tested in the delivery of a hydrophobic drug, curcumin through an in–vitro procedure. The results show that the release percentage of curcumin was increased with the presence of the co–carrier. The intermolecular interaction of curcumin with albumin and the competition between them to locate on the surface of silica affect the release system. Besides, the curcumin release amount was corresponded to the composition of the silica carrier in the systems. Consequently, the potential for silica/albumin use as a drug carrier was ascertained.
Keywords
  • silica,
  • albumin,
  • curcumin,
  • co–carrier,
  • composition,
  • release mechanism,
  • intermolecular interaction
Publication Date
2018
Citation Information
Shafiyah Pondi, Wai Loon Leaw, Sheela Chandren and Hadi Nur. "Release of curcum inincorporated in albumin loaded silica" Malaysian Journal of Fundamental and Applied Sciences Vol. 14 Iss. 1 (2018) p. 109 - 115
Available at: http://works.bepress.com/hadi_nur/153/