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Article
Innate immune response and hepatic inflammation
Gastroenterology Publications and Presentations
  • Gyongyi Szabo, University of Massachusetts Medical School
  • Pranoti Mandrekar, University of Massachusetts Medical School
  • Angela Dolganiuc, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Gastroenterology; Department of Medicine, Rheumatology Division
Publication Date
11-6-2007
Document Type
Article
Subjects
Animals; Cytokines; Humans; Immunity, Innate; Inflammation; Liver; Liver Diseases; Models, Biological
Abstract
Inflammation is a pathogenic component of various types of acute and chronic liver diseases, and it contributes to progressive liver damage and fibrosis. Cells of the innate immune system initiate and maintain hepatic inflammation though mediator production as a result of their activation by pathogen-derived products recognized by pattern recognition receptors. Innate immune cells, particularly dendritic cells, have a pivotal role in sensing pathogens and initiating adaptive immune responses by activation and regulation of T-lymphocyte responses. Although the liver provides a "tolerogenic" immune environment for antigen-specific T-cells, activation of Kupffer cells, recruited macrophages, and inflammatory cells results in production of cytokines and chemokines that can lead to prolonged inflammation, hepatocyte damage, and/or cholestasis. The specificity of Toll-like receptors and the mechanisms of innate immune cell activation are discussed in relation to acute and chronic liver injury including viral, alcoholic, nonalcoholic, and drug-induced hepatitis.
DOI of Published Version
10.1055/s-2007-991511
Source
Semin Liver Dis. 2007 Nov;27(4):339-50. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
17979071
Citation Information
Gyongyi Szabo, Pranoti Mandrekar and Angela Dolganiuc. "Innate immune response and hepatic inflammation" Vol. 27 Iss. 4 (2007) ISSN: 0272-8087 (Linking)
Available at: http://works.bepress.com/gyongyi_szabo/90/