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Article
Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets
UMass Metabolic Network Publications
  • Gyongyi Szabo, University of Massachusetts Medical School
  • Fatemeh Momen-Heravi, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Gastroenterology; UMass Metabolic Network
Publication Date
8-1-2017
Document Type
Article
Abstract

Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics.

DOI of Published Version
10.1038/nrgastro.2017.71
Source
Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):455-466. doi: 10.1038/nrgastro.2017.71. Epub 2017 Jun 21. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
28634412
Citation Information
Gyongyi Szabo and Fatemeh Momen-Heravi. "Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets" (2017) ISSN: 1759-5045 (Linking)
Available at: http://works.bepress.com/gyongyi_szabo/216/