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Article
Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice
University of Massachusetts Medical School Faculty Publications
  • Arvin Iracheta-Vellve, University of Massachusetts Medical School
  • Jan Petrasek, University of Massachusetts Medical School
  • Benedek Gyongyosi, University of Massachusetts Medical School
  • Shashi Bala, University of Massachusetts Medical School
  • Timea Csak, University of Massachusetts Medical School
  • Karen Kodys, University of Massachusetts Medical School
  • Gyongyi Szabo, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Gastroenterology; Graduate School of Biomedical Sciences, Translational Science Program; UMass Metabolic Network
Publication Date
3-27-2017
Document Type
Article
Abstract

BACKGROUND and AIMS: Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown.

METHODS: Here we tested IL-1 receptor antagonist to block IL-1 signaling in a mouse model of acute-on-chronic liver injury on liver inflammation and hepatocyte regeneration in AH.

RESULTS: We observed that inhibition of IL-1 signaling decreased liver inflammation, neutrophil infiltration, enhanced regeneration of hepatocytes, and resulted in increased rate of recovery from liver injury in AH.

CONCLUSION: Our novel findings suggest that IL-1 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.

Keywords
  • alcoholic liver disease,
  • interleukin 1,
  • interleukin 1 receptor antagonist,
  • liver regeneration
DOI of Published Version
10.1111/liv.13430
Source
Liver Int. 2017 Mar 26. doi: 10.1111/liv.13430. Link to article on publisher's site
Comments

First author Arvin Iracheta-Vellve is a doctoral student in the Translational Science program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
28345165
Citation Information
Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyongyosi, Shashi Bala, et al.. "Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice" (2017) ISSN: 1478-3223 (Linking)
Available at: http://works.bepress.com/gyongyi_szabo/209/