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Article
Role of MicroRNAs in NAFLD/NASH
University of Massachusetts Medical School Faculty Publications
  • Gyongyi Szabo, University of Massachusetts Medical School
  • Timea Csak, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Gastroenterology; UMass Metabolic Network
Publication Date
5-1-2016
Document Type
Article
Abstract

MicroRNAs (miRNAs) are highly conserved, small, 18-25 nucleotide, non-coding RNAs that regulate gene expression at the post-transcriptional level. Each miRNA can regulate hundreds of target genes, and vice versa each target gene can be regulated by numerous miRNAs, suggesting a very complex network and explaining how miRNAs play pivotal roles in fine-tuning essentially all biological processes in all cell types in the liver. Here, we summarize the current knowledge on the role of miRNAs in the pathogenesis and diagnosis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with an outlook to the broader aspects of metabolic syndrome. Furthermore, we discuss the role of miRNAs as potential biomarkers and therapeutic targets in NAFLD/NASH.

Keywords
  • MicroRNAs,
  • NAFLD,
  • NASH
DOI of Published Version
10.1007/s10620-015-4002-4
Source
Dig Dis Sci. 2016 May;61(5):1314-24. doi: 10.1007/s10620-015-4002-4. Epub 2016 Jan 14. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
26769057
Citation Information
Gyongyi Szabo and Timea Csak. "Role of MicroRNAs in NAFLD/NASH" Vol. 61 Iss. 5 (2016) ISSN: 0163-2116 (Linking)
Available at: http://works.bepress.com/gyongyi_szabo/204/