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Article
Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model.
Journal of Surgical Research (2011)
  • C Lauder
  • G Garcea
  • A Strickland
  • Guy Maddern
Abstract
Background: Intra-abdominal adhesions are a major cause of morbidity and a significant drain on health-care resources. Numerous anti-adhesion products have reached clinical use but none has been wholly satisfactory. This study examines the application of a modified chitosan-dextran (CD) gel to the intraperitoneal cavity to reduce adhesion formation. This is a unique synthetic gel, its active ingredients being sccinyl chitosoan and dextran aldehyde. Conclusions: Chitosan-dextran gel appears to significantly reduce the formation of intra-abdominal adhesions without adversely affecting wound healing. This is a noteworthy advancement in the safe prevention of post operative, intra-abdominal adhesions.
Keywords
  • adhesions,
  • peritoneum,
  • adhesion barrier,
  • adhesion prevention,
  • abdominal surgery
Disciplines
Publication Date
2011
Citation Information
C Lauder, G Garcea, A Strickland and Guy Maddern. "Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model." Journal of Surgical Research Vol. 171 Iss. 2 (2011)
Available at: http://works.bepress.com/guy_maddern/37/