Article
Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction
Green Chemistry Letters and Reviews
(2016)
Abstract
Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.
Keywords
- Ionic liquids,
- indole,
- Fischer indole synthesis,
- tetramethylguanidinium,
- biodegradable
Disciplines
Publication Date
January, 2016
DOI
10.1080/17518253.2016.1149231
Citation Information
William C. Neuhaus, Ian J. Bakanas, Joseph R. Lizza, Charles T. Boon, et al.. "Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction" Green Chemistry Letters and Reviews Vol. 9 Iss. 1 (2016) p. 39 - 43 ISSN: 1751-8253 Available at: http://works.bepress.com/gustavo-moura-letts/7/