Article
Rutile Promoted Synthesis of Sulfonylamidonitriles from Simple Aldehydes and Sulfonamides
ACS Sustainable Chemistry & Engineering
(2016)
Abstract
We report the first rutile-promoted synthesis of sulfonylamidonitriles from aldehydes and sulfonamides with NaCN in water. This transformation has proven to work for a variety of aliphatic and aromatic aldehydes with excellent yields. The scope also extends to a variety of substituted sulfonamides. Rutile can be easily recycled and reused without significant reaction erosion. The benign nature of rutile and its natural abundance highlights this transformation as a model green reaction.
Keywords
- Green reaction,
- Heterogeneous catalysis,
- Rutile,
- Strecker reaction,
- Sulfonylamidonitriles
Disciplines
Publication Date
April, 2016
DOI
10.1021/acssuschemeng.6b00241
Citation Information
Nicholas V. Costantini, Alex D. Bates, Graham J. Haun, Natasha M. Chang, et al.. "Rutile Promoted Synthesis of Sulfonylamidonitriles from Simple Aldehydes and Sulfonamides" ACS Sustainable Chemistry & Engineering Vol. 4 Iss. 4 (2016) p. 1906 - 1911 ISSN: 2168-0485 Available at: http://works.bepress.com/gustavo-moura-letts/6/