Article
Alumina-promoted synthesis of N-aryl-1,2,4-triazoles from substituted hydrazines and imides
Tetrahedron Letters
(2016)
Abstract
Herein we report the highly efficient, environmentally friendly alumina-promoted synthesis of N-aryl-1,2,4-triazoles with a wide variety of substitution patterns from commercially available hydrazines with symmetrical and unsymmetrical imides. Aromatic hydrazines with a variety of substitution patterns provided the corresponding 1,2,4-triazoles in very high yields. Unsymmetrical imides with a wide variety of functional groups also provide the respective triazoles with high yield and complete regioselectivities. The high productivity and mild conditions allow for the large-scale preparation of 1,2,4-triazoles.
Keywords
- Alumina-promoted reactions,
- Green chemistry,
- Imides,
- 1,
- 2,
- 4-Triazoles
Disciplines
Publication Date
November, 2016
DOI
10.1016/j.tetlet.2016.09.086
Citation Information
William C. Neuhaus and Gustavo Moura-Letts. "Alumina-promoted synthesis of N-aryl-1,2,4-triazoles from substituted hydrazines and imides" Tetrahedron Letters Vol. 57 Iss. 45 (2016) p. 4974 - 4977 ISSN: 0040-4039 Available at: http://works.bepress.com/gustavo-moura-letts/4/