Article
Direct Synthesis of Cyanopyrrolidinyl β-Amino Alcohols for the Development of Diabetes Therapeutics
European Journal of Organic Chemistry
(2016)
Abstract
Cyanopyrrolidinyl β-amino alcohols are novel scaffolds with potential for a wide array of pharmacological properties. We have discovered that we can selectively access these scaffolds from simple and inexpensive commercially available chemicals in few synthetic steps with minimal purification. We have produced a 36-compound library of these scaffolds and tested them as dipeptidyl peptidase IV (DPP4) inhibitors. These novel inhibitors are useful in the treatment of diabetes and inflammatory disorders.
Keywords
- Medicinal chemistry,
- Diabetes therapeutic,
- Inhibitors,
- Nitrogen heterocycles,
- Epoxides,
- Amino alcohols
Disciplines
Publication Date
October, 2016
DOI
10.1002/ejoc.201600969
Citation Information
Joseph R. Lizza, Savan V. Patel, Catherine F. Yang and Gustavo Moura-Letts. "Direct Synthesis of Cyanopyrrolidinyl β-Amino Alcohols for the Development of Diabetes Therapeutics" European Journal of Organic Chemistry Vol. 2016 Iss. 30 (2016) p. 5160 - 5168 ISSN: 1434-193X Available at: http://works.bepress.com/gustavo-moura-letts/3/