Article
Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters
European Journal of Organic Chemistry
(2016)
Abstract
Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and β-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted β-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.
Keywords
- Tetrasubstituted pyrazoles,
- Pyrazolones,
- Nitrogen heterocycles,
- Cyclization,
- Reaction mechanisms
Disciplines
Publication Date
November, 2016
DOI
10.1002/ejoc.201601093
Citation Information
Ian J. Bakanas and Gustavo Moura-Letts. "Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters" European Journal of Organic Chemistry Vol. 2016 Iss. 32 (2016) p. 5345 - 5349 ISSN: 1434-193X Available at: http://works.bepress.com/gustavo-moura-letts/2/