Article
Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols
Synthesis
(2016)
Abstract
An efficient synthesis of β-amino alcohols from a variety of epoxides and primary unbranched amines in the absence of any catalyst in high yields and regioselectivities is reported. A variety of polar mixed solvent systems allow for the selective formation of secondary amino alcohols over tertiary amino alcohols. The reaction scope extends to a wide variety of aromatic and aliphatic substituted epoxides and primary amines bearing complex functionality.
Keywords
- β-amino alcohols,
- primary amines,
- epoxide opening reactions,
- solvent-directed reactions,
- β-blockers
Disciplines
Publication Date
2016
DOI
10.1055/s-0036-1588356
Citation Information
Joseph R. Lizza and Gustavo Moura-Letts. "Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols" Synthesis (2016) Available at: http://works.bepress.com/gustavo-moura-letts/1/