This chapter examines several research partnerships between the Tecnológico de Monterrey and various US university counterparts. The study presented here is based on data from interviews with five principal liaisons and from document analysis. It seeks to develop a deeper understanding of motives and perceptions surrounding the research projects. Findings indicate that collaborations have enhanced Mexican faculty research productivity, advanced human resource capacity development, and generated useful and marketable applied research. US institutions have also expanded their research trajectories through these partnerships and improved their related knowledge bases. The chapter ends by offering alternative policies to promote research collaboration and exchange of knowledge with potential for impacting regional economies.