The research examines the association between Local Health Departments (LHDs) Health Informatics (HI) capacity and Emergency Preparedness (EP) capacity using the 2013 National Association of County and City Health Officials (NACCHO) Profile study. The purpose is to identify potential Health Informatics Capacities that can possibly improve Emergency Preparedness of LHDs. We conducted a secondary analysis of the data from the 2013 NACCHO Profile study, a cross-sectional study used to develop a thorough description of infrastructure and practice of LHDs. All 2,532 LHDs in the U.S. received a core set of questions, but only a sub-sample of LHDs received a survey containing questions about emergency preparedness and informatics capacity. The sub-sample consisted of 625 LHDs of which 505 LHDs completed the survey (81% response rate). This sample was selected using stratified random sampling without replacement which assigned LHDs the core survey or core plus one of two modules. We examined five ordinal measures for the areas of informatics with three response categories of each as well as five measures for the area of emergency preparedness with two response categories of each. The study illustrates a significant relationship between variables of HI and EP, the results can be used by LHDs to improve their HI capacities to better their EP capacity.