Objectives: This study estimates the rates of chlamydia, gonorrhea, and genital herpes simplex virus before and after spring break and homecoming week (and during summer terms) at a southeastern American university.

Participants: Participants comprised students who utilized the campus student health center from January 1st 2006, to December 31st, 2008.

Methods: Retrospective de-identified participants’ data were extracted using the specific diagnoses codes for each illness via the on-campus student health center’s electronic medical record and practice management system. Enrollment data were obtained from the university’s catalogue on the registrar’s website.

Results: The rates of the three illnesses and average times to diagnoses from the first date of infected participants’ enrollment are estimated.

Conclusions: The rates of these illnesses at this campus’s student health center were higher after spring break, homecoming, and summer Term A. Infected participants were on average diagnosed within their first two years of enrollment at the university.