This paper proposes an integrated model for a multi-period reverse logistics (RL) network design problem under return and demand uncertainty. The reverse logistics network is modeled as a two-stage stochastic programming model to make strategic and tactical decisions. The strategic decisions are the first stage decisions in establishing network’s facilities and tactical decisions are the second stage decisions on material flow, inventory, backorder, shortage, and outsourcing. The uncertainties considered in this study are the primary market return and secondary market demand. The model aims to determine optimal numbers of sorting centers and warehouses, optimal lot sizes, and transportation plan that minimize the expected total system cost over the planning horizon. A case study was conducted to validate the proposed model. Numerical results indicate that the stochastic model solution outperforms result of expected value solution.