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About Gretchen Mahler

Our lab uses microfluidics and 3D scaffolds to create physiologically realistic cell culture models of organs and tissues. These in vitro models can be engineered to signal cells using biochemical and biomechanical pathways, help to minimize animal testing, and provide tightly controlled, reproducible experimental conditions. The goal of our work is to replicate some of the cell-cell and cell-extracellular matrix interactions not easily studied in vivo or in silico to better understand how cells behave during disease and respond to chemicals or drugs. Our current research has applications toward cardiovascular disease and cancer and focuses on how disruptions in a tissue's local mechanical environment can lead to changes in cell phenotype and disease initiation and progression.


Present Assistant Professor, Binghamton University--SUNY