Skip to main content
Article
Pediatric liver transplantation for acute liver failure at a single center: A 10-yr experience
Pediatric transplantation
  • Thomas Heffron
  • Todd Pillen
  • Gregory Smallwood, Philadelphia College of Osteopathic Medicine
  • John Rodriguez
  • Sundari Sekar
  • Stuart Henry
  • Miriam Vos
  • Katherine Casper
  • Nitika Arora Gupta
  • Carlos G. Fasola
Document Type
Article
Publication Date
1-1-2010
Abstract
Children transplanted for ALF urgently require an optimal graft and have lower post-transplant survival compared with children transplanted for chronic liver disease. Over 10 yr, 33 consecutive children transplanted for ALF were followed. Demographics, encephalopathy, intubation, dialysis, laboratory values, graft type ABOI, XL (GRWR > 5%), DDSLT, LDLT and WLT were evaluated. Complications and survival were determined. ALF accounted for 33/201 (16.4%) of transplants during this period. Twelve of 33 received ABOI, five XL grafts, 18 DDSLT, and three LDLT. Waiting time pretransplant was 2.1 days. One- and three-yr patient survival in the ALF group was 93.4% and 88.9%, and graft survivals were 86.4% and 77.7%. Median follow-up was 1452 days. ABOI one- and three yr patient and graft survival in the ALF was 91.6% and 78.6%. No difference in graft or patient survival was noted in the ALF and chronic liver disease group or the ABOI and the ABO compatible group. A combination of ABO incompatible donor livers, XL grafts, DDSLT, LDLT and WLT led to a short wait time and subsequent graft and patient survival comparable to patients with non-acute disease. © 2009 John Wiley & Sons A/S.
Comments

This article was published in Pediatric transplantation, Volume 14, Issue 2, Pages 228-232.

The published version is available at http://dx.doi.org/10.1111/j.1399-3046.2009.01202.x.

Copyright © 2010 Wiley.

Citation Information
Thomas Heffron, Todd Pillen, Gregory Smallwood, John Rodriguez, et al.. "Pediatric liver transplantation for acute liver failure at a single center: A 10-yr experience" Pediatric transplantation Vol. 14 Iss. 2 (2010) p. 228 - 232
Available at: http://works.bepress.com/gregory_smallwood/35/