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Hepatitis g virus co-infection in liver transplantation recipients with chronic hepatitis c and nonviral chronic liver disease
Hepatology
  • M. W. Fried
  • Y. E. Khudyakov
  • Gregory Smallwood, Philadelphia College of Osteopathic Medicine
  • M. Cong
  • B. Nichols
  • E. Diaz
  • P. Siefert
  • K. Gutekunst
  • R. D. Gordon
  • T. D. Boyer
Document Type
Article
Publication Date
1-1-1997
Abstract
Hepatitis G virus (HGV) is a newly described RNA virus that is parenterally transmitted and has been found frequently in patients with chronic hepatitis C infection. To determine the impact of hepatitis G virus co-infection on morbidity and mortality following liver transplantation, we measured HGV RNA by polymerase chain reaction in pre and posttransplantation sera from a cohort of patients transplanted for chronic hepatitis C and a control group of patients transplanted for nonviral causes who were negative for hepatitis C virus (HCV) RNA in serum. The overall prevalence rate of HGV RNA in transplanted patients with chronic hepatitis C was 20.7%. HGV infection was present before transplantation in 13% while it appeared to have been acquired at the time of transplantation in 7.4%. Mean serum alanine aminotransferase activity, hepatic histological activity, and patient and graft survival were similar between HGV-positive and HGV-negative patients. The prevalence rate of HGV RNA in transplanted controls was 64% (P < .01) with a significantly higher rate of acquisition of HGV infection following transplantation (53%, P < .001) when compared with patients with chronic hepatitis C. Mean serum alanine aminotransferase activity was significantly lower in the control patients with HGV infection alone following transplantation than in patients co-infected with hepatitis C (37 ± 9 vs. 70 ± 33 U/L, P < .01). Thus, HGV is frequently found in transplantation patients co-infected with hepatitis C although it appears to have minimal clinical impact. In patients transplanted for nonviral causes of end-stage liver disease, a high rate of hepatitis G acquisition at the time of transplantation may occur but does not appear to predispose to chronic hepatitis.
Comments

This article was published in Hepatology, Volume 25, Issue 5, Pages 1271-1275.

The published version is available at http://dx.doi.org/10.1002/hep.510250536 .

Copyright © 1997 AASLD.

Citation Information
M. W. Fried, Y. E. Khudyakov, Gregory Smallwood, M. Cong, et al.. "Hepatitis g virus co-infection in liver transplantation recipients with chronic hepatitis c and nonviral chronic liver disease" Hepatology Vol. 25 Iss. 5 (1997) p. 1271 - 1275
Available at: http://works.bepress.com/gregory_smallwood/28/