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Selected Works of Gregory Wiedman
Article
Synergies with and Resistance to Membrane-Active Peptides
Antibiotics (2020)
  • Adam Kmeck, Seton Hall University
  • Robert J. Tancer, Seton Hall University
  • Cristina R. Ventura, Seton Hall University
  • Gregory R. Wiedman, Seton Hall University
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Abstract
Membrane-active peptides (MAPs) have long been thought of as the key to defeatingantimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In thisreview, we seek to highlight some of the common pathways for resistance, as well as some avenuesfor potential synergy. This discussion takes place considering resistance, and/or synergy in theextracellular space, at the membrane, and during interaction, and/or removal. Overall, this reviewshows that researchers require improved definitions of resistance and a more thorough understandingof MAP-resistance mechanisms. The solution to combating resistance may ultimately come from anunderstanding of how to harness the power of synergistic drug combinations.
Keywords
  • membrane-active peptides,
  • antimicrobial-resistance,
  • drug synergy
Disciplines
Publication Date
September 19, 2020
DOI
10.3390/ANTIBIOTICS9090620
Citation Information
Adam Kmeck, Robert J. Tancer, Cristina R. Ventura and Gregory R. Wiedman. "Synergies with and Resistance to Membrane-Active Peptides" Antibiotics Vol. 9 (2020) p. 620 ISSN: 2079-6382
Available at: http://works.bepress.com/gregory-wiedman/2/