The soybean cyst nematode (SCN) is the most damaging pathogen of soybeans in the United States. Farmers in Iowa successfully managed SCN for many years by growing SCN-resistant soybeans in rotation with corn. However, almost all resistant varieties contain SCN resistance genes from the same breeding line, named PI 88788. Not surprisingly, SCN populations in fields throughout the state are overcoming the PI 88788 resistance because of use of those resistance genes for more than 30 years.